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國立陽明大學生理學科暨研究所
歡迎來到國立陽明大學生理學科暨研究所
王錫崗

  個人資料 研究方向 代表著作 五年內執行計畫 實驗室成員 (2016.03.15 update)

姓名 王錫崗  

王錫崗

職稱 兼任教授
通訊電話

02-2826-7082        

傳真號碼 02-2826-4049        
電子信箱 pswang@ym.edu.tw
學歷          

  國立台灣大學動物系學士(1972)

研究所 國立台灣大學動物學研究所碩士(1974)
            
美國伊利諾大學獸醫學院哲學博士(1980)

經歷

臺灣內分泌及代謝學會理事長 2014~迄今

亞洲大學健康學院生物科技學系 講座教授 2012/9/10~2013/6/26

中國醫藥大學醫學院老化醫學博士學位學程 講座教授兼主任 2012/8/1~2014/1/31

中國醫藥大學附屬醫院老化醫學研究中心 教授兼主任 2012/8/1~迄今   

調適醫學 主編 2009/7/1~迄今

國立陽明大學實驗動物中心主任 2005/7/1~ 2009/12/31

國立陽明大學醫學院 副院長 2002/8/1~2005/7/31 

中國生理學雜誌 主編 1990/1/1~1995/12/31; 2002/1/1~迄今          

國立陽明大學生理學研究所 教授 1994/8/1~迄今          

國立陽明醫學院生理學科 教授 1988/8/1~1994/7/31 

國立陽明醫學院生理學科及生理學研究所科 主任兼所長 1986/10/1~1992/7/31 

國立陽明醫學院生理學科 副教授 1980/4/1~1988/7/31 

中央研究院動物研究所 助理研究員 1974/8/1~1975/7/31 
研究方向

主要興趣包括(1)臨床藥物及中藥對腎上腺皮質及性腺類固醇激素合成及分泌之藥理及毒理效應,(2)臨床藥物及中藥對人前列腺癌及乳癌細胞增生及細胞週期之效應,(3)大鼠胃排空及小腸傳輸之激素及藥物調節,(4)運動或低氧訓練對大鼠激素、骨骼肌蛋白或免疫系統之影響。主要利用放射免疫測定法分析蛋白激素及類固醇激素之濃度,並利用西方點墨法及RT-PCR技術檢測蛋白表現及基因表現。目前實驗室有研究助理、碩士生、博士生、博士後研究員以及合作教師一起參與上述研究,並與台北榮總內科部的婦產部和泌尿外科,以及台北市立醫院陽明院區之一般外科、眼科及胸腔科進行多年的合作。

代表著作 (2005-迄今,*表通訊作者)

1

Yu, P.L., Lin, T.M., Wang, S.W.*, and Wang, P.S.* Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. Free Radical Res. 46:718-725, 2012. (* Equal Contributions)

2

Chang, L.L. and Wang P.S.* Effects of vitamin E on steroidogenesis in rat zona fasciculata-reticularis cells. Adapt. Med. 4: 75-80, 2012.

3

Pu, H.F., Lin, C.W., Lee, H.W., and Wang, P.S.* Effects of propylthiouracil on the production of aldosterone in rat zona glomerulosa cells. Adapt. Med. 4: 245-250, 2012.

4

Chang, L.L.*, Wun, W.S.A., and Wang P.S.In utero and neonate exposure to nonylphenol develops hyperadrenalism and metabolic syndrome later in life. I. First generation rats (F1). Toxicology 301: 40-49, 2012. (* Equal Contributions)

5

Chang, F.Y.*, Lu, C.L., Chen, T.S., and Wang, P.S. The role of cholecystokinin 1 receptor in prolactin inhibited gastric emptying of male rat. J. Neurogastroenterol. Motil. 18:385-390, 2012.

6

Chang, J.W., Tsai, H.L., Chen, C.W., Yang, H.W., Yang, A.H., Yang, L.Y., Wang, P. S., Ng, Y.Y., Lin, T.L. and Lee, O.K.* Conditioned mesenchymal stem cells attenuate progression of chronic kidney disease through inhibition of epithelial-to-mesenchymal transition and immune modulation. J. Cell. Mol. Med. 16:2935-2949, 2012.

7

Wang, K.L., Hsia, S.M., Chan, C.J., Huang, C.Y., Bau, D.T., Chang, F.Y., and Wang, P.S.* Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin. Ther. Tar. 17: 337-349, 2013.

8

Bau, D.T.*, Pu, H.F., Tsai, C.W., and Wang, P.S. Steady progresses of the Chinese Journal of Physiology in 2011. Chinese J. Physiol. 56: 58-60, 2013.

9

Chuang, T.Y., Chang, F.Y., Juan, C.C., and Wang, P.S.* Adaptive roles of adiponectin and resistin in cardiovascular disease. Adapt. Med. 5: 21-28, 2013.

10

Chang, H.C., Yang, Y.R., Wang, P.S., Kuo, C.H., and Wang, R.Y.* The neuroprotective effects of intramuscular insulin-like growth factor-1 treatment in brain ischemic rats. PLoS ONE 8:e64015, 2013.

11

Wang, K.L., Hsia, S.M., Yeh, J.Y., Cheng, S.C. Wang, P.S.*, and Wang, S.W.* Anti-proliferative effects of evodiamine on human breast cancer cells. PLoS ONE 8: e67297, 2013.

12

Chang, L.L.*, Wun W.S., and Wang, P.S.* Recovery from developmental nonylphenol exposure is possible I. Male. J. Biol. Agricul. Healthc. 3:118-130, 2013.

13

Hwang, G.S., Hu, S., Lin, Y.H., Chen, S.T., Tang, T.K., Wang, P.S.*, and Wang, S.W.* Arecoline inhibits interleukin-2 secretion in jurkat cells by decreasing the expression of cyclooxygenase-2, alpha7-nicotinic acetylcholine receptors and prostaglandin E2. J. Physiol. Pharmacol. 64:535-543, 2013.

14

Lin, C.S., Pei, K.J.C. *, Wang, P.S., and B.T. Liu. Evidence of higher levels of testosterone during the velvet period in muntjac than in other cervids. Theriogenology 81: 403-406, 2014.

15

Lieu, F.K., Lin, C.Y., Wang, P.S., Jian, C.Y., Yeh, Y.H., Chen, Y.A., Wang, K.L., Lin, Y.C., Chang, L.L., Wang, G.J., and Wang, S.W.* Effect of swimming on the production of aldosterone in rats. PLoS ONE (In Press)

16

Chang, H.C., Yang, Y.R., Wang, P.S., and Wang, R.Y.* Quercetin enhances exercise- mediated neuroprotective effects in brain ischemic rats. Med. Sci. Sports Exer. 46: 1908-1916, 2014.

17

Chang, Y.J., Hwu, C.M., Yeh, C.C., Wang, P.S.*and Wang, S.W.* Subacute hypothyroidism on metabolism and growth-related molecules. Molecules. 19: 11178-11195, 2014.

18

Wang, Z.H., Hsu, H.W., Chou, J.C., Yu C.H., Bau, D.T., Wang, G.J., Huang C.Y., Wang, P.S., and Wang, S.W.* Cytotoxic effect of S-petasin and iso-S-petasin on the proliferation of human prostate cancer cells. Anticancer Res. 35:191-199, 2015.

19

Weng, T.C. and Wang, P.S.* Biological regulation of aging process. Adapt. Med. 7: 18-25, 2015.

20

Wang, K.L., Hsia, S.M., Chang, Y.C., Chou, J.C., Lieu, F.K., Tsai, P.C., Wang, S.W.*, and Wang, P.S.* Adaptation of testosterone production in response to low-dose effects of nonylphenol. Adapt. Med. 7: 44-51, 2015.

21

Manfo, F.P.T. *, Nantia, E.A., Beboy, S.N.E., Moundipa, P.F., Pugeat, M., and Wang, P.S. Medicinal plants as treatment option of male reproductive dysfunction. Adapt. Med. 7:57-72, 2015.

22

Yu, P.L., Cheng, S.Y., Chou J.C., Pan, W.H.T., Wang, S.W.,* and Wang, P.S.* Regulation of intermittent hypoxia on brain dopamine in amphetaminized rats. Chinese J. Physiol. 58:219-227, 2015.

23

Chang, Y.J., Wang, P.S., Wang, S.W.,* and Hwu, C.M.* Effect of liquid formula on plasma glucose, insulin, and ghrelin levels in healthy humans with mixed meal tests. Adapt. Med. 8:24-31, 2016.

24

Yeh, J.Y., Chiao, Y.C., Lin, H., and Wang, P.S.* Involvement of cholecystokinin (CCK) receptor in the adaptation of gastric emptying induced by adrenocorticotropin (ACTH) in male rats. Adapt. Med. 8:40-44, 2016.

25

Chang, L. L., Wun, W.S.A., and Wang, P.S.* Nonylphenol-induced hyperadrenalism can be reversed/ alleviated by inhibiting of II-β hydroxysteroid dehydroglnase type I. Environ. Toxicol. Pharmacol. 44: 1-12, 2016.
26 Chou, J.C., Kan, S.F., Lieu, F.K., Soong, C., Tsai, S.C., Lin, C.Y., Wang, P.S.* and Wang, S.W.* Inhibitory effects of propylthiouracil on corticosterone production in rat zona fasciculata-reticularis cells. Pharmacologia 7(2-3): 83-92, 2016.
27 Wang, K.L., Huang, W.C., Chou, J.C., Weng, T.C., Hu, S., Lieu, F.K., Lai, W.H., Idova, G., Wang, P.S.,* and Wang, S.W*. Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids 111: 89-94, 2016.
28 Yeh, Y.H., Chou, J.C., Weng, T.C., Lieu, F.K., Lin, J.Y., Yeh, C.C., Hu, S., Wang, P.S.,* Idova, G., and Wang, S.W.* Effects of acrolein on the production of corticosterone in male rats. Steroids 111:139-147, 2016.
29 Chen, C.W., Jian, C.Y., Lin, P.H., Chen C.C., Lieu, F.K., Soong, C., Hsieh, C.C., Wan, C.Y., Idova, G., Hu, S., Wang, S.W.,* and Wang, P.S.* Role of testosterone in regulating induction of TNF-α in rat spleen via ERK signaling pathway. Steroids 111: 148-154, 2016.
30 Wang, P.S. and Chang, L.L.* Effects of nonylphenol on hyperadrenalism and metabolism in male rats. J. Metab. Invest. 2:e1379, 2016.
31 Lin, P.H., Jian, C.Y., Chou, J.C., Chen, C.W., Chen, C.C., Soong, C., Hu, S., Lieu, F.K.*, Wang, P.S.*, and Wang S.W*. Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Sci. Rep.6: 32085, 2016.
32 Chen, C.W., Chen, C.C., Jian, C.Y., Lin, P.H., Chou, J.C., Teng H.S., Hu, S., Lieu, F.K., Wang, P.S.*, and Wang, S.W. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes J. Appl. Physiol. 2016 [in press]
33 Chen, C.W., Hu, S., Wang, P.S., Hwu, C.M., and Wang, S.W. Testosterone as a regulator of immune system via modulation of toll-like receptor 4/extracellular signal-regulated kinase signaling pathway. Inflamm. Cell Signal. 3: e1407, 2016.
TOP
五年內執行計畫

1.睪酮對不同年齡雄性大鼠腎臟SMP30蛋白表現及功能之效應 (科技部,2014/08/01~2016/07/31)

2.鞣花酸及熊果酸對飲食來源醣化物之老化促進的延緩作用 (科技部,2014/08/01~2015/07/31)

3.【愛之味股份有限公司】愛之味飲品之動物實驗分析 (產學合作計畫,2013/04/01~2014/08/31)

4.老化對雄性大鼠生殖系統之效應及影響機制 (國科會,2012/08/01~2013/07/31)

5.以動物及細胞模型探討性類固醇對雌性生殖及代謝之影響--(總計畫與子計畫五)性腺類固醇與泌乳素對雌鼠下視丘-腦下腺-腎上腺皮質軸線之效應 (國科會,2011/08/01~2014/07/31)

6.甲狀腺激素在調節飢餓激素與類胰島素生長因子對胃腸表現之交互作用中所扮演之角色 (國科會,2011/08/01~2013/07/31)

實驗室成員

博士生:陳建瑋、陳智傑、林伯涵、孫嘉宏、何積泓、簡彩雲  

研究助理:周柔君

博士後研究員:翁鼎鈞

TOP

2013 Annual Meeting of the SSR, Montréal, Canada

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2012 Annual Meeting of the SSR, Pennsylvania , U.S.A

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2011 Annual Meeting of the SSR, Portland , U.S.A 

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2011 Satellite Symposia of FAOPS, Taipei, Taiwan 

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