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國立陽明大學生理學科暨研究所
歡迎來到國立陽明大學生理學科暨研究所
阮琪昌

 個人資料  研究方向  代表著作 五年內執行計畫 實驗室成員  (2016.03.15  update) 

姓名

阮琪昌

阮琪昌

 

職稱

教授兼主任所長 

通訊電話

02-2826-7085

傳真號碼

02-2826-4049

電子信箱

ccjuan@ym.edu.tw

學歷

大  學 東海大學生物學系學士(1991

研究所 國立陽明大學生理學碩士(1993

       國立陽明大學生理學博士(1998

經歷

台北榮民總醫院教學研究部

博士後研究 (1998~2003)

研究方向

主要的研究興趣是(1)代謝症候群病理機轉的探討、2)具血管活性因子對新陳代謝的影響、(3)重組蛋白質的表現及活性探討、(4)脂肪組織分泌之細胞因子在肥胖及胰島素抗拒症致病機轉中的角色探討5)藥物及保健食品的開發。實驗對象包括細胞、組織、小鼠以及大白鼠等。研究方法則涵蓋細胞生理學、內分泌學、生物化學以及分子生物學等相關技術的操作。

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代表著作

 
01 Chen JY, Jian DY, Lien CC, Lin YT, Ting CH, Chen LK, Hsu TC, Huang HM, Wu YT, Kuan TT, Chao YW, Wu LY, Huang SW, Juan CC*. Adipocytes play an etiological role in the podocytopathy of high-fat diet-fed rats. J Endocrinol. 231: 109-120, 2016.
02 Huang YH, Jian DY, Lien CC, Juan CC*. Short-Term Hypoxia-Induced Inhibition of Adipogenesis and Enhancement of Insulin Sensitivity in 3T3-L1 Adipocytes Adaptive Medicine 8: 12-23, 2016.
03 Lin YT, Jian DY, Kwok CF, Ho LT, Juan CC*. Visfatin Promotes Foam Cell Formation by Dysregulating Cd36, Sra, Abca1 and Abcg1 Expression in Raw264.7 Macrophages. Shock. 45: 460-468, 2016.
04 Lien cc, Jiang JL, Jian DY, Kwok CF, Ho LT, Juan CC*. Chronic endothelin-1 infusion causes adipocyte hyperplasia in rats. Obesity. 24: 643-53, 2016.
05 How CK, Hou SK, Chen LK, Yang CM, Huang HH, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC*. Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion. J Trauma Acute Care Surg. 79: 592-601, 2015.
06 Chang CJ, Jian DY, Lin MW, Zhao JZ, Ho LT, Juan CC*. Evidence in Obese Children: Greater Contribution of Hyperlipidemia than Those of Obesity-Inflammation and Insulin Sensitivity. PLoS One. 10: e0125935, 2015.
07 Juan CC, Chen KH, Wang PH, Hwang JL, Seow KM. Endocannabinoid system activation might be associated to insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 104: 200-206, 2015.
08 Lin YJ, Juan CC, Kwok CF, Hsu YP, Shih KC, Chen CC, Ho LT. Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome. Biochem Biophys Res Commun. 460: 497-503, 2015.
09 How CK, Hou SK, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC*. Expression profile of MicroRNAs in gram-negative bacterial sepsis. Shock. 43: 121-127, 2015.
10 Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC (Co-first author), Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cell Signal. 26: 2940-2950, 2014.
11 Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC, Ho LT. Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor. Biochem Biophys Res Commun. 451: 263-269, 2014.
12 Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH. Endothelin-1 stimulates resistin gene expression. Endocrinology. 155: 854-864, 2014.
13 Chuang TY, Chang FY, Juan CC, Wang PS. Adaptive Roles of Adiponectin and Resistin in Cardiovascular Diseases. Adaptive Medicine 5: 21-28, 2013.
14 Ho LT, Hsu YP, Hsiao CF, Ting CT, Shih KC, Chuang LM, Masaki K, Grove J, Quertermous T, Juan CC, Lin MW, Chiang SC, Chen YD. Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study. Front Endocrinol (Lausanne). 4:172, 2013.
15 Jian DY, Chao YW, Ting CH, Huang SW, Chang CF, Juan CC*, Chen JY. Losartan ameliorates renal injury, hypertension, and adipocytokine imbalance in 5/6 nephrectomized rats. Eur J Pharmacol.709:85-92, 2013.
16  Seow KM, Lin YH, Wang PH, Hwang JL, Ho LT,Juan CC*. Aquaglyceroporin-7 overexpression in women with the polycystic ovary syndrome. Gynecol Obstet Invest. 75: 126-131, 2013.
17 How CK, Chien Y, Yang KY, Shih HC, Juan CC, Yang YP, Chiou GY, Huang PI, Chang YL, Chen LK, Wang CY, Hsu HS, Chiou SH, Lee CH. Induced pluripotent stem cells mediate the release of interferon gamma-induced protein 10 and alleviate bleomycin-induced lung inflammation and fibrosis. Shock. 39: 261-270, 2013.
18 Seow KM, Lee JL, Doong ML, Huang SW, Hwang JL, Huang WJ, Chang FY, Ho LT, Juan CC*.  Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats. J Endocrinol. 216: 307-314, 2013.
19 Chen CY, Ho LT, Yang FY, Juan CC*. Au LC. Prunellae Spica extract contains antagonists for human endothelin receptors. Am J Chin Med. 41: 85-98, 2013.
20 Liu TY, Chen CY, Juan CC*. , Au LC. Coding region of adiponectin contains a silent intron reactivated by the adjacent intervening sequence of vector. Plasmid. 69(1):67-71, 2013.
21 Wei TY, Juan CC (Co-first author), Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103: 1640-1650, 2012.
22 Seow KM, Juan CC, Wang PH, Ho LT, Hwang JL. Expression levels of vascular cell adhesion molecule-1 in young and nonobese women with polycystic ovary syndrome. Gynecol Obstet Invest. 73: 236-241, 2012.
23 Chai SP, Juan CC, Kao PH, Wang DH, Fong JC. Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes. Int J Obes (Lond). 37: 197-203, 2013.
24 Seow KM, Hwang JL, Wang PH, Ho LT, Juan CC*.  Expression of visfatin mRNA in peripheral blood mononuclear cells is not correlated with visfatin mRNA in omental adipose tissue in women with polycystic ovary syndrome. Hum Reprod. 26: 2869-2873, 2011.
25 Chuang TY, Au LC, Wang LC, Ho LT, Yang DM, Juan CC*.Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells. J Cell Physiol. 227: 1610-1618, 2012.
26 Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL. PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells. J Atheroscler Thromb. 18: 966-980, 2011.
27 Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, Ho LT, Kwok CF, Juan CC*. Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol. 226: 2181-2188, 2011.
28 Seow KM, Lin YH, Hwang JL, Wang PH, Ho LT, Lin YH, Juan CC*.  Expression levels of haem oxygenase-1 in the omental adipose tissue and peripheral blood mononuclear cells of women with polycystic ovary syndrome. Hum Reprod. 26: 431-437, 2011.
29 Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC*. Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology. 152: 384-393, 2011.
30 Seow KM, Tsai YL, Juan CC, Huang LW, Hwang JL, Ho LT. Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. Gynecol Obstet Invest. 69: 51-56, 2010.
31 Seow KM, Tsai YL, Juan CC, Lin YH, Hwang JL, Ho LT. Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS: a preliminary study. Reprod Biomed Online. 19: 577-82, 2009.
32 Lien CC, Au LC, Tsai YL, Ho LT,  Juan CC*.  Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. Endocrinology. 150: 4892-4900, 2009.
33 Seow KM, Tsai YL, Hwang JL, Hsu WY, Ho LT,  Juan CC*. Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome. Hum Reprod. 24: 1982-1988, 2009.
34 Chen HS, Wu TE, Juan CC, Lin HD. Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats. J Endocrinol. 200:151-157, 2009.
35  Juan CC, Au LC, Yang FY, Yang DM, Ho LT. An endothelin type A receptor-expressing cell to characterize endothelin-1 binding and screen antagonist. Anal Biochem. 379: 27-31, 2008.
36 Juan CC*, Lien CC, Chang CL, Huang YH, Ho LT. Involvement of iNOS and NO in TNF-alpha-downregulated Resistin Gene Expression in 3T3-L1 Adipocytes. Obesity (Silver Spring). 16: 1219-1225, 2008. 
37 Seow KM, Juan CC, Hwang JL, Ho LT. Laparoscopic surgery in polycystic ovary syndrome: reproductive and metabolic effects. Semin Reprod Med. 26: 101-110, 2008.
38 Juan CC*. , Chuang TY, Lien CC, Lin YJ, Huang SW, Kwok CF, Ho LT. Leptin increases endothelin type A receptor levels in vascular smooth muscle cells. Am J Physiol Endocrinol Metab. 294: E481-E487, 2008.

*

Corresponding author.

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五年內執行計畫

1.探討以芍藥為基底的複合性食材對於改善肥胖伴生代謝症候群之效應 (農委會) 2012.06.012013.12.31

2.透過表現具脂締素受體脂細胞篩選治療糖尿病之潛力藥物 (國科會) 2012.05.012015.04.30

3.開發改善肥胖誘發代謝症候群之保健食品-開發預防肥胖發生之保健食品(國科會) 2009.08.012012.07.31

4.內皮素及一氧化氮對脂肪細胞形成之調節作用及其分子機轉 (國科會) 2009.08.012012.07.31

5.建立篩選改善婦女停經後併發代謝症候群的保健食品之功效評估方法 (衛生署) 2009.03.012010.02.28 

6.抗胰島素蛋白對血管功能的效應及其分子機轉之探討(3/3) (國科會) 2008.08.012009.07.31

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實驗室成員

碩士班:官澤庭、黃萱閔、許庭嘉、黃太嫈

博士班:林于婷連之嬋、陳倫魁

研究助理:林宜秀、吳宇庭

博士後研究員: 

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