Your browser does not support JavaScript!
國立陽明大學生理學科暨研究所
歡迎來到國立陽明大學生理學科暨研究所
吳鈺琳

 個人資料  研究方向  代表著作 五年內執行計畫 實驗室成員  (2016.07.06 update)

姓名

吳鈺琳

 

 

 

 

 

職稱

教授 (02/2017-迄今)

通訊電話

(O) 02-2826-7081   (Lab) 02-2826-7000 Ext. 5943

傳真號碼

(02)2826-4049

電子信箱

ylwu@ym.edu.tw

學歷

成功大學生物系學士(1990

台灣大學醫學院微生物學研究所碩士(1992

美國威斯康辛大學馬迪遜校區內分泌及生殖生理學博士(2001

經歷

陸軍少尉(19921994

台大醫學院微生物學研究所助教(199495

美國北卡羅萊那大學教堂崗校區博士後研究(20012004

國立陽明大學生理所助理教授(2004∼2010)

國立陽明大學生理所副教授(2010∼2017)

研究方向

研究理念:

    實驗室的訓練首重責任及獨立,幫助研究生養成獨立思考的習慣及能力,並運用到研究專題及日常生活中,希望培養出能真正獨立做研究的科學家。在論文寫作及Seminar的報告積極鼓勵研究生以英文來完成。 

研究方向:

    本實驗室“細胞訊息傳遞實驗室”藉由細胞生物學,生化學,分子生物學及生理學的角度來探討內分泌系統及免疫系統功能(發炎反應)相關之分子調控機轉,及其在生理、病理或癌症進程中之角色。另外,我們也研究日常生活中所攝取之營養補品(glucosamine,中藥等等)在生理上所扮演的角色及其在細胞內的標的分子與基因群等等。

主要研究課題包含有:

1.分子內分泌之訊息傳遞在細胞生理之角色及其所參與之反應機制探究。

2.免疫(發炎)反應在生殖系統中生理及病理之分子作用機制探討。

3.抗發炎藥物在生理和病理狀態下的角色及其對癌症的療效和作用機制研究。

4. Glucosamine的生理角色及其對發炎反應及癌細胞的作用與相關機制研究。

top

代表著作

1 Chen HT, Sun D, Peng YC, Kao PH, Wu YL*. Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and interleukin-8 production in human breast cancer cells. Innate Immunity  2017;23:54-66 (*Correspondence)
2 Chao YN, Sun D, Peng YC, Wu YL*. Growth hormone releasing peptide-2 attenuation of protein kinase C-induced inflammation in human ovarian granulosa cells. International Journal of Molecular Sciences 2016 Aug 19;17(8). pii: E1359. doi: 10.3390/ijms17081359 (*Correspondence)
3 Ou HL, Sun D, Peng YC, Wu YL*. Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1b-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells. Innate Immunity  2016; 22:452-465. (*Correspondence)
4 Peng YC, Lin CL, Yeh HZ, Chang CS, Wu YL, Kao CH. Association Between the Use of Proton Pump Inhibitors and the Risk of ESRD in Renal Diseases: A Population-Based, Case-Control Study. Medicine (Baltimore) 2016 Apr;95(15):e3363. doi: 10.1097/MD.0000000000003363.
5 Peng YC, Lin CL, Hsu WY, Chang CS, Yeh HZ, Tung CF, Wu YL, Sung FC, Kao CH. Statins are associated with a reduced risk of Cholangiocarcinoma: a population-based case-control study. Br J Clin Pharmacol. 2015;80:755-761
6 Chou WY, Chuang KH, Sun D, Lee YH, Kao PH, Lin YY, Wang HW, Wu YL*. Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine. J Cell Physiol. 2015;230:2240-2251
7 Chien HY, Lu CS, Chuang KH, Kao PH, Wu YL*. Attenuation of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by lysophosphatidic acid in macrophages. Innate Immun. 2015;21:635-646.
8 Wu YL. Lin AH, Chen CH, Huang WC, Wang HY, Liu MH, Lee TS, Kou YR. Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Free Radic Biol Med. 2014;69:208-218.
9 Chuang KH, Peng YC, Chien HY, Lu ML, Du HI, Wu YL*. Attenuation of Lipopolysaccharide-induced Lung Inflammation by Glucosamine in Rats. Am J Respir Cell Mol Biol. 2013 49:1110-1119. (*Correspondence)
10 Chuang KH, Lu CS, Kou YR, Wu YL*. Cell Cycle Regulation by Glucosamine in Human Pulmonary Epithelial Cells. Pulmonary Pharmacology and Therapeutics 2013;26:195-204. (*Correspondence)
11 Salim S, Asghar M, Taneja M, Hovatta I, Wu YL, Saha K, Sarraj N, Hite B. Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Lett 2011;585:1375-1381.
12 Tang GJ, Wang HY, Wang JY, Lee CC, Tseng HW, Wu YL, Shyue SK, Lee TS, Kou YR. Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice. Free Radic Biol Med 2011;50:1492-502.
13 Chen CY, Shyue SK, Ching LC, Su KH, Wu YL, Kou YR, Chiang AN, Pan CC, Lee TS. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutr Biochem 2011;22:1015-1021. [Epub ahead of print]
14
Cheng LC, Su KH, Kou YR, Shyue SK, Ching LC, Yu YB, Wu YL, Pan CC, Lee TS. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radical Biology and Medicine 2011;50:47-54.
15 Wu YL*, Kou YR, Ou HL, Chien HY, Chuang KH, Liu HH, Lee TS, Tsai CY, Lu ML. Glucosamine Regulation of LPS-mediated Inflammation in Human Bronchial Epithelial Cells. European Journal of Pharmacology 2010;635:219-226. (*Correspondence)
16 Chen CY, Shyue SK, Ching LC, Su KH, Wu YL, Kou YR, Chiang AN, Pan CC, Lee TS. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutritional Biochemistry 2011;22:1015-1021.
17 Cheng LC, Su KH, Kou YR, Shyue SK, Ching LC, Yu YB, Wu YL, Pan CC, Lee TS. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radical Biology and Medicine 2011;50:47-54.
18 Tsai JY, Su KH, Shyue SK, Kou YR, Yu YB, Hsiao SH, Chiang AN, Wu YL, Ching LC, Lee TS. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. Cardiovasc Res 2010;88:415-423.
19 Tsai CY, Lee TS, Kou YR, Wu YL*. Glucosamine Inhibits IL-1b-mediated IL-8 Production in Prostate Cancer Cells by MAPK Attenuation. Journal of Cellular Biochemistry 2009; 108:489-498. (*Correspondence)
20 Hsu CL, Wu YL, Tang GJ, Lee TS, Kou YR. Ginkgo Biloba Extract Confers Protection from Cigarette Smoke Extract-induced Apoptosis in Human Lung Endothelial Cells: Role of Heme Oxygenase-1. Pulmonary Pharmacology and Therapeutics 2009; 22:286-296.
21 Su KH, Tsai JY, Kou YR, Chang AN, Hsiao SH, Wu YL, Hou HH, Pan CC, Shyue SK, Lee TS. Valsartan Regulates the Interaction of Angiotensin II Type 1 Receptor and Endothelial Nitric Oxide Synthase via Src/PI3K/Akt Signaling. Cardiovascular Research 2009; 82:468-475.
22 Lee TS, Lin CY, Tsai JY, Wu YL, Su KH, Lu KY, Hsiao SH, Pan CC, Kou YR, Hsu YP, Ho LT. Resistin Increases Lipid Accumulation byAffecting Class A Scavenger Receptor, CD36 and ATP-binding Cassette Transporter-A1 in Macrophages. Life Sciences 2009; 84:97-104.
23 Cheng YS, Lee TS, Hsu HC, Kou YR, Wu YL*. Characterization of the Transcriptional Regulation of the Regulator of G Protein Signaling 2 (RGS2) Gene during 3T3-L1 Preadipocyte Differentiation. Journal of Cellular Biochemistry 2008; 105:922-930. (*Correspondence)
24 Lee TS, Liu YJ, Tang GJ, Yien HW, Wu YL, Kou YR.Wood Smoke Extract Promotes both Apoptosis and Proliferation in Rat Alveolar Epithelial Type II Cells: the Role of Oxidative Stress and Heme Oxygenase-1. Critical Care of Medicine 2008; 36:2597-2606.
25 Wu YL*, Chuang HH, Kou YR, Lee TS, Lu SH, Huang YC, Nishi Y, Yanase T. Regulation of LH Receptor and PGF2Receptor Signaling by the Regulator of G Protein Signaling 2 (RGS2) in Human and Mouse Granulosa Cells. Chinese Journal of Physiology 2008; 51:282-291.(*Correspondence)
26 Yang YL, Tang GJ, Wu YL, Yien HW, Lee TS, Kou YR. Exacerbation of Wood Smoke-induced Acute Lung Injury by Mechanical Ventilation Using Moderately High Tidal Volume in Mice. Respiratory Physiology & Neurobiology 2008; 160:99-108.
Top
五年內執行計畫
科技部:葡萄糖胺對骨肉瘤之角色研究(08/01/2016 ~ 7/31/2019)

科技部:飢餓素對卵巢發炎反應及固醇類激素生合成之角色及機制探討

(08/01/2013 ~ 7/31/2016)

科技部:以細胞及動物模式探討性類固醇對卵巢發炎反應之重要性及其分子作用機制

(08/01/2011 ~ 7/31/2014)

科技部:葡萄糖胺對肺臟發炎反應之效益評估及其作用機轉和標的分子探討

(08/01/2011 ~ 7/31/2012)

行政院衛福部:蟾蜍靈對細胞發炎反應的效益評估及其作用機制和標的分子探討

(01/01/2011 ~ 12/31/2011)

科技部:探討葡萄糖胺對攝護腺發炎及攝護腺癌之角色

(08/01/2008 ~ 10/31/2010)

 

 

 

 

 

 

top 

image

 

瀏覽數  
將此文章推薦給親友
請輸入此驗證碼
Voice Play
更換驗證碼